I sleep so much better now and wake up with a clear head. The tension I used to carry around all day is mostly gone.
Annika F. Verified Purchase
4.7 10 reviews

Selank

The calming peptide studied for anxiety, stress and memory.

  • Based on tuftsin, a peptide the human body makes naturally
  • Matched a standard anti-anxiety drug in 62 adults
  • Also studied for focus and immune health
£20,00
Bacteriostatic water 2ml vial FREE
1 free BAC water with every vial Worth £8 a bottle. Added automatically.
Add to cart
In Stock - Ships within 24h
How to use Selank Our own 17-step illustrated guide, from mixing to storage.
I sleep so much better now and wake up with a clear head. The tension I used to carry around all day is mostly gone.
Annika F. Verified Purchase
Description

What Is Selank?

Selank is a synthetic analogue of the naturally occurring immunomodulatory peptide tuftsin, developed alongside Semax at the Institute of Molecular Genetics of the Russian Academy of Sciences. While Semax was designed for cognitive enhancement, Selank was developed as an anxiolytic (anti-anxiety) agent – and it has been prescribed in Russia since 2009 for generalised anxiety disorder and neurasthenia.

What makes Selank remarkable in the anxiolytic space is what it doesn’t do: it reduces anxiety without sedation, without tolerance buildup, without dependency risk, and without cognitive impairment. Benzodiazepines (the standard pharmaceutical anxiolytics) provide anxiety relief but at the cost of drowsiness, impaired memory, addiction risk, and cognitive fog. Selank provides comparable anxiety reduction while actually enhancing cognitive function – a combination that no traditional anxiolytic achieves.

How Selank Reduces Anxiety

  • GABA modulation: Selank enhances GABAergic transmission – the brain’s primary inhibitory (calming) system – but through allosteric modulation rather than direct agonism. This means it increases GABA’s effectiveness without the blunt suppression that causes sedation and dependency with benzodiazepines.
  • Serotonin regulation: Selank modulates serotonin metabolism, stabilising the neurotransmitter most directly associated with mood, emotional resilience, and well-being. It inhibits the enzyme that breaks down enkephalins (natural mood-elevating peptides), prolonging their positive effects.
  • Dopamine stabilisation: By balancing dopamine levels, Selank prevents both the apathy of low dopamine and the restlessness of excess dopamine, contributing to a stable, focused emotional state.
  • Immune modulation: As a tuftsin analogue, Selank retains immunomodulatory properties – it can normalise the production of inflammatory cytokines that are often elevated during chronic stress and contribute to anxiety symptoms. This mind-body connection makes Selank uniquely effective for stress-related anxiety.
  • BDNF increase: Like Semax, Selank increases Brain-Derived Neurotrophic Factor, supporting neuroplasticity and cognitive function even while reducing anxiety.

Selank vs Traditional Anxiolytics

The comparison with benzodiazepines highlights Selank’s advantages: equivalent anxiety reduction without sedation, no tolerance development (the dose doesn’t need to increase over time), no physical dependency or withdrawal risk, no cognitive impairment (actually enhances cognition), and no interaction with alcohol. For individuals seeking anxiety relief who cannot afford the cognitive costs of traditional medications, Selank offers a compelling alternative.

Who Benefits from Selank?

Selank is ideal for individuals with generalised anxiety who want relief without sedation, professionals who need to remain sharp under high-stress conditions, those experiencing social anxiety who want confidence without impairment, people transitioning off benzodiazepines who need non-addictive support, and anyone with chronic stress-related inflammation affecting mood and well-being.

Clinical References
Selank, a Novel Anxiolytic Peptide, Modulates GABA-A Receptor Subunit Expression
Kasian A, Kolomin T, Andreeva L, et al.

Front Pharmacol, 2017. PubMed →

Anxiolytic-Like Effect of Selank in Elevated Plus-Maze
Semenova TP, Kozlovskii II, et al.

Bull Exp Biol Med, 2007. PubMed →

The Effects of Selank on the BDNF Gene Expression in the Rat Hippocampus
Inozemtseva LS, Karpenko EA, et al.

Dokl Biol Sci, 2008. PubMed →

Clinical References

  1. Semenova TP, Kozlovskii II, Zakharova NM, et al. Experimental optimization of learning and memory processes by selank. Eksp Klin Farmakol. 2010;73(8):2-5. PubMed 20919548
  2. Zozulia AA, Neznamov GG, Siuniakov TS, et al. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. PubMed 18454096
  3. Zozulya AA, Kost NV, Yu Sokolov O, et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001;131(4):315-317. PubMed 11550013
  4. Medvedev VE, Tereshchenko ON, Israelian AIu, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22. PubMed 25176261
  5. Volkova A, Shadrina M, Kolomin T, et al. Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Front Pharmacol. 2016;7:31. PubMed 26924987
  6. Filatova E, Kasian A, Kolomin T, et al. GABA, Selank, and olanzapine affect the expression of genes involved in GABAergic neurotransmission in IMR-32 cells. Front Pharmacol. 2017;8:89. PubMed 28293190
  7. Narkevich VB, Kudrin VS, Klodt PM, et al. Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study. Eksp Klin Farmakol. 2008;71(5):8-12. PubMed 19093364
  8. Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, et al. The influence of Selank on the level of cytokines under the conditions of "social" stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162-167. PubMed 32621722
  9. Uchakina ON, Uchakin PN, Miasoedov NF, et al. Immunomodulatory effects of selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-75. PubMed 18577961
  10. Kolik LG, Nadorova AV, Antipova TA, et al. Selank, peptide analogue of tuftsin, protects against ethanol-induced memory impairment by regulating of BDNF content in the hippocampus and prefrontal cortex in rats. Bull Exp Biol Med. 2019;167(5):641-644. PubMed 31625062
  11. Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behav Neurol. 2017;2017:5091027. PubMed 28280289
Product specifications
Dosage
200mcg – 600mcg daily (intranasal)
Cycle
2–4 weeks
Form
10mg lyophilised powder
Purity
≥98%
Molecular formula
C₃₃H₅₇N₁₁O₉
Storage
2–8°C refrigerated
Dosing guide

Category-Specific Dosing Guides

If you plan to buy Selank online, it is important to understand the standard preparation and administration methods used in published protocols and product documentation. Selank is typically administered intranasally, similar to Semax. Available evidence and clinical use have not associated it with the sleep-related considerations commonly reported for some other neuroactive compounds.

  1. 1

    Reconstitute

    Add 2 ml of BAC water to the 10 mg vial to achieve a concentration of 5 mg/ml. Transfer the solution to a nasal spray bottle. Most standard nasal sprayers deliver approximately 0.1 ml per spray, equivalent to around 500 mcg at this concentration.

  2. 2

    Dosing

    Typical protocols use 200-600 mcg daily via intranasal administration. This amount can be taken as a single dose or divided throughout the day. Unlike Semax, Selank is commonly administered in the evening in both investigative and clinical settings. Some protocols evaluate administration during acute stress-related conditions.

  3. 3

    Cycle

    Most protocols run for 2-4 weeks, followed by a 2-week break. Some studies have also evaluated longer cycles of up to 6 weeks. Published studies report that effects may develop during the first week of administration and remain stable throughout the treatment period.

Shipping and returns

Free shipping on orders over £220.

Cognitive Protocol - 3 Weeks Save £8,00

Focus + anxiolytic + sleep - full nootropic triad. · 3 Weeks

Semax
Semax 10mg lyophilised powder
£20,00
Selank
2× Selank 10mg lyophilised powder
£40,00
DSIP
DSIP 5mg lyophilised powder
£20,00
£72,00 £80,00 Save £8,00

Selank matched a standard anti-anxiety drug in 62 adults

In a trial of 62 adults with anxiety or neurasthenia, Selank eased anxiety as much as medazepam. Selank also had an anti-fatigue effect.

GABA receptors - mice

38% more GABA receptor binding in the brain

ControlBaseline
Selank+38%

Anxious mice got Selank daily for 5 days. Injected Selank raised GABA receptor binding in the frontal cortex by 38%. GABA is the brain's main calming signal. Nasal Selank raised NMDA receptor binding by 23% instead.

Vasil'eva et al., Eksperimental'naia i Klinicheskaia Farmakologiia, 2016

Sources: Zozulia AA et al., Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova 2008;108(4):38-48; Vasil'eva EV et al., Eksperimental'naia i Klinicheskaia Farmakologiia 2016;79(9):3-11; Medvedev VE et al., Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova 2014;114(7):17-22; Semenova TP et al., Eksperimental'naia i Klinicheskaia Farmakologiia 2010;73(8):2-5; Leonidovna YA et al., Current Reviews in Clinical and Experimental Pharmacology 2021;16(2):162-167

Rated 4.7 by verified buyers

Customer rating 4.7 Based on 10 reviews Write a review
2026-03-24

I sleep so much better now and wake up with a clear head. The tension I used to carry around all day is mostly gone.

Annika F. Verified Purchase
2026-03-07

Subtle but real anxiolytic effect. Pairs well with Semax for a balanced cognitive stack. Good European source.

Pavel S. Verified Purchase

Leave a Review

Share your experience. Your email won't be published.

0 / 300
Photos (optional)

    Optional · up to 5 photos · JPG, PNG or WebP · max 5 MB each

    How to use Selank

    Ready in 4 steps, BAC water included. A complete visual guide to preparing, reconstituting, injecting, and storing your peptides safely. Follow each step in order.

    Step 1: Supplies laid out
    1. Supplies laid out Gather your supplies: peptide vial, bacteriostatic water, syringes, alcohol swabs, cotton ball, and bandage.
    Step 2: Remove / flip caps
    2. Remove / flip caps Remove the plastic caps from both vials to expose the rubber stoppers.
    Step 3: Swab the vial stopper
    3. Swab the vial stopper Wipe the top of each vial with an alcohol swab. Let air-dry.
    Step 4: Draw BAC water
    4. Draw BAC water Draw the required amount of bacteriostatic water into the syringe. Use our calculator if unsure.
    Step 5: Inject water into vial
    5. Inject water into vial Inject the water slowly into the peptide vial, letting it run down the inside wall. Do not spray directly onto the powder.
    Step 6: Swirl to dissolve
    6. Swirl to dissolve Gently swirl the vial until the powder dissolves. Do not shake.
    Step 7: Check the solution
    7. Check the solution Check the solution: no undissolved particles, no bubbles, clear liquid. If not, wait and swirl again.
    Step 8: Draw your dose
    8. Draw your dose Draw your dose slowly from the reconstituted peptide vial.

    This peptide is administered intranasally, not via injection. Follow the steps below.

    9. Transfer solution Transfer the reconstituted solution into a nasal spray bottle.
    10. Prime the sprayer Pump 2–3 times into the air until a fine mist appears.
    11. Administer Tilt your head slightly forward. Insert the nozzle into one nostril, angled slightly outward. Press and inhale gently. Repeat for the other nostril if directed.
    12. Wait Avoid blowing your nose for 10–15 minutes after administration.
    Step 17: Storage
    13. Storage Store reconstituted peptides in the fridge (2-8 °C). Avoid freezing and direct sunlight. Use within 90 days.

    Pre-filled for this product. Adjust values to match your protocol.

    Concentration —
    Volume Per Dose —
    Insulin Syringe Units —
    Total Doses Per Vial —
    Open full calculator

    Frequently Asked Questions