Using for longevity research. Sleep quality improved noticeably in the first cycle. The science behind telomerase activation is fascinating.
Katarina M. Verified Purchase
4.7 10 reviews

Epitalon

The pineal peptide studied for healthy aging and longevity.

  • Based on a peptide the body makes naturally
  • Helped aging human cells live longer in a lab study
  • Also studied for melatonin and sleep rhythm
Price range: £40,00 through £280,00
Bacteriostatic water 2ml vial FREE
1 free BAC water with every vial Worth £8 a bottle. Added automatically.
In Stock - Ships within 24h
How to use Epitalon Our own 17-step illustrated guide, from mixing to storage.
Using for longevity research. Sleep quality improved noticeably in the first cycle. The science behind telomerase activation is fascinating.
Katarina M. Verified Purchase
Description

What Is Epitalon?

Epitalon (also written as Epithalon or Epithalone) is a synthetic tetrapeptide consisting of four amino acids (Ala-Glu-Asp-Gly) based on the naturally occurring Epithalamin peptide produced by the pineal gland. Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology over 35 years of research, Epitalon is the most extensively studied peptide for its effects on telomerase activation and cellular longevity.

At its core, Epitalon targets one of the most fundamental mechanisms of biological aging: telomere shortening. Every time a cell divides, the protective caps on the ends of chromosomes (telomeres) get slightly shorter. When telomeres become critically short, the cell can no longer divide and enters senescence or dies. Epitalon activates telomerase – the enzyme that rebuilds telomere length – essentially helping to reset this biological clock.

How Epitalon Works: The Science of Telomeres

  • Telomerase activation: Epitalon’s primary mechanism is the activation of telomerase, the ribonucleoprotein enzyme that adds telomeric DNA (TTAGGG repeats) to the ends of chromosomes. By maintaining telomere length, cells retain their ability to divide and function normally for longer.
  • Pineal gland regulation: Epitalon stimulates the pineal gland to produce melatonin at more youthful levels. Melatonin production naturally declines with age, and restoring it improves sleep architecture, circadian rhythm regulation, and antioxidant defence.
  • Gene expression: Research has shown Epitalon can modulate gene expression patterns, activating genes associated with cellular repair and youth while dampening those associated with aging and senescence.
  • Antioxidant capacity: Epitalon enhances the body’s endogenous antioxidant systems, reducing oxidative stress – one of the primary drivers of cellular aging and damage.

Research & Legacy

Professor Khavinson’s research on Epitalon spans over three decades and includes human clinical studies. His work demonstrated that Epithalamin (the natural peptide Epitalon is based on) reduced mortality rates by 28% in an elderly population over a 12-year follow-up period. Laboratory studies showed Epitalon increased telomere length in human cells by activating the telomerase gene hTERT, and extended the lifespan of cell cultures beyond the Hayflick limit.

Beyond telomeres, users consistently report improved sleep quality, enhanced morning alertness, and a general sense of vitality during Epitalon cycles – likely mediated through its effects on melatonin and pineal gland function.

Who Uses Epitalon?

Epitalon appeals to anyone interested in longevity science and proactive aging support. It is popular among individuals over 35 who want to address cellular aging before visible signs appear, biohackers focused on optimising healthspan, and those experiencing age-related sleep deterioration who want a non-sedative approach to improving sleep quality.

Clinical References
Peptide Bioregulation of Aging: Results and Prospects
Khavinson VK

Adv Gerontol, 2020. PubMed →

Effect of Epithalon on Telomerase Activity and Telomere Length in Human Somatic Cells
Khavinson VK, Bondarev IE, Butyugov AA

Bull Exp Biol Med, 2003. PubMed →

Epitalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells
Khavinson VK, Bondarev IE, Butyugov AA, et al.

Neuro Endocrinol Lett, 2003. PubMed →

Clinical References

  1. Araj SK, Brzezik J, Madra-Gackowska K, et al. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. PubMed 40141333
  2. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. PubMed 12374906
  3. Khavinson VKh, Kuznik BI, Tarnovskaia SI, et al. Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data. Adv Gerontol. 2014;27(3):399-406. PubMed 25826983
  4. Khavinson VK, Kopylov AT, Vaskovsky BV, et al. Identification of Peptide AEDG in the Polypeptide Complex of the Pineal Gland. Bull Exp Biol Med. 2017;164(1):41-43. PubMed 29124531
  5. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PubMed 12937682
  6. Khavinson V, Goncharova N, Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro Endocrinol Lett. 2001;22(4):251-254. PubMed 11524632
  7. Korkushko OV, Khavinson VKh, Shatilo VB, et al. Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people. Bull Exp Biol Med. 2004;137(4):389-391. PubMed 15452611
  8. Khavinson V, Diomede F, Mironova E, et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. 2020;25(3):609. PubMed 32019204
  9. Korkushko OV, Khavinson VKh, Shatilo VB, et al. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006;142(3):356-359. PubMed 17426848
  10. Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. PubMed 14523363
  11. Khavinson VKh, Bondarev IE, Butyugov AA, et al. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004;137(5):503-506. PubMed 15455129
Product specifications
Dosage
5mg – 10mg daily
Cycle
10–20 days, repeated 2–3x yearly
Form
10mg lyophilised powder
Purity
≥98%
Molecular formula
C₁₄H₂₂N₄O₉
Storage
Room temperature (below 25°C)
Dosing guide

Category-Specific Dosing Guides

How to Use Epitalon It’s commonly used in short courses repeated several times throughout the year. Typical protocols involve 10–20 consecutive days of use, followed by several months without administration.

  1. 1

    Reconstitute

    Add 2ml of bacteriostatic (BAC) water to the 10mg vial to achieve a concentration of 5mg/ml. The lyophilized powder dissolves quickly and usually requires only a gentle swirl.

  2. 2

    Dosing Protocol

    Epitalon dosage protocol consists of 5–10mg daily for a sustained use over 10–20 days. Many users follow a protocol of 10mg daily for 20 days. Administration is generally performed via subcutaneous injection in the abdominal area.

  3. 3

    Repeat 2–3 Times Per Year

    Protocols are often repeated 2-3 times per year, with courses spaced approximately 4-6 months apart. Some users choose to schedule courses around seasonal transitions, such as spring and autumn.

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Longevity Protocol - Standard (~8 wk) Save £56,00

Core longevity stack - cellular, skin, mitochondrial. · Standard (~8 wk)

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Aging human cells divided 10 more times with Epitalon

Human cells that had stopped dividing at passage 34 grew their telomeres back to early-passage length with Epitalon. They reached passage 44 and kept dividing.

Longevity
Elderly heart patients - 12-year trial

28% fewer deaths after 12 years

Elderly people with heart disease took Epithalamin, the natural pineal extract Epitalon is modelled on. After 12 years, 28% fewer had died than in the control group on the same basic treatment. Heart-related deaths were half as common.

Korkushko et al., Bulletin of Experimental Biology and Medicine, 2006
Melatonin
Rhesus monkeys - animal study

Night melatonin back up in old monkeys

Old monkeys had less melatonin at night than young ones. Epitalon raised their night melatonin and lowered their resting glucose and insulin. It made no difference in young monkeys.

Goncharova et al., Experimental Gerontology, 2005
DNA
Mice - lifelong study

17.1% fewer chromosome errors

Mice got Epitalon 5 days a month from 3 months of age until death. Their bone marrow cells showed 17.1% fewer chromosome aberrations. Average lifespan did not change, but the longest-living 10% lived 13.3% longer.

Anisimov et al., Biogerontology, 2003

Sources: Khavinson VKh, Bondarev IE, Butyugov AA, Smirnova TD, Bulletin of Experimental Biology and Medicine 2004;137(5):503-6; Anisimov VN et al., Bulletin of Experimental Biology and Medicine 2002;134(2):187-90; Korkushko OV et al., Bulletin of Experimental Biology and Medicine 2006;142(3):356-9; Goncharova ND et al., Experimental Gerontology 2005;40(1-2):51-7; Anisimov VN et al., Biogerontology 2003;4(4):193-202

Rated 4.7 by verified buyers

Customer rating 4.7 Based on 10 reviews Write a review
March 2026

Using for longevity research. Sleep quality improved noticeably in the first cycle. The science behind telomerase activation is fascinating.

Katarina M. Verified Purchase
March 2026

Subtle effects but consistent. Skin elasticity seems better and overall recovery from workouts improved. On my second cycle.

Anton K. Verified Purchase

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    How to use Epitalon

    Ready in 4 steps, BAC water included. A complete visual guide to preparing, reconstituting, injecting, and storing your peptides safely. Follow each step in order.

    Step 1: Supplies laid out
    1. Supplies laid out Gather your supplies: peptide vial, bacteriostatic water, syringes, alcohol swabs, cotton ball, and bandage.
    Step 2: Remove / flip caps
    2. Remove / flip caps Remove the plastic caps from both vials to expose the rubber stoppers.
    Step 3: Swab the vial stopper
    3. Swab the vial stopper Wipe the top of each vial with an alcohol swab. Let air-dry.
    Step 4: Draw BAC water
    4. Draw BAC water Draw the required amount of bacteriostatic water into the syringe. Use our calculator if unsure.
    Step 5: Inject water into vial
    5. Inject water into vial Inject the water slowly into the peptide vial, letting it run down the inside wall. Do not spray directly onto the powder.
    Step 6: Swirl to dissolve
    6. Swirl to dissolve Gently swirl the vial until the powder dissolves. Do not shake.
    Step 7: Check the solution
    7. Check the solution Check the solution: no undissolved particles, no bubbles, clear liquid. If not, wait and swirl again.
    Step 8: Draw your dose
    8. Draw your dose Draw your dose slowly from the reconstituted peptide vial.
    Step 9: Remove air bubbles
    9. Remove air bubbles Hold the syringe needle-up, flick to move air bubbles to the top, and push the plunger until a small drop appears.
    Step 10: Choose injection site
    10. Choose injection site Choose your injection site: belly fat around the navel or outer thigh. Rotate sites between injections.
    Step 11: Clean the site
    11. Clean the site Clean the injection site with an alcohol swab.
    Step 12: Pinch skin
    12. Pinch skin Pinch a fold of skin at the injection site to lift the subcutaneous fatty tissue away from the muscle.
    Step 13: Insert at 45°
    13. Insert at 45° Insert the needle at a 45° angle into the subcutaneous fatty tissue, usually approximately half the needle length. Do not inject into muscle. Inject slowly.
    Step 14: Cotton-ball press
    14. Cotton-ball press Withdraw the needle and press a cotton ball gently on the site for a few seconds.
    Step 15: Apply bandage
    15. Apply bandage Apply a small bandage.
    Step 16: Sharps disposal
    16. Sharps disposal Dispose of the needle in a sharps container.
    Step 17: Storage
    17. Storage Store reconstituted peptides in the fridge (2-8 °C). Avoid freezing and direct sunlight. Use within 90 days.

    Pre-filled for this product. Adjust values to match your protocol.

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