Got a deep, golden tan in under two weeks with barely any sun time. Friends keep asking where I went on holiday. Great product.
Björn T. Verified Purchase
Description
What Is Selank?
Selank is a synthetic analogue of the naturally occurring immunomodulatory peptide tuftsin, developed alongside Semax at the Institute of Molecular Genetics of the Russian Academy of Sciences. While Semax was designed for cognitive enhancement, Selank was developed as an anxiolytic (anti-anxiety) agent – and it has been prescribed in Russia since 2009 for generalised anxiety disorder and neurasthenia.
What makes Selank remarkable in the anxiolytic space is what it doesn’t do: it reduces anxiety without sedation, without tolerance buildup, without dependency risk, and without cognitive impairment. Benzodiazepines (the standard pharmaceutical anxiolytics) provide anxiety relief but at the cost of drowsiness, impaired memory, addiction risk, and cognitive fog. Selank provides comparable anxiety reduction while actually enhancing cognitive function – a combination that no traditional anxiolytic achieves.
How Selank Reduces Anxiety
GABA modulation: Selank enhances GABAergic transmission – the brain’s primary inhibitory (calming) system – but through allosteric modulation rather than direct agonism. This means it increases GABA’s effectiveness without the blunt suppression that causes sedation and dependency with benzodiazepines.
Serotonin regulation: Selank modulates serotonin metabolism, stabilising the neurotransmitter most directly associated with mood, emotional resilience, and well-being. It inhibits the enzyme that breaks down enkephalins (natural mood-elevating peptides), prolonging their positive effects.
Dopamine stabilisation: By balancing dopamine levels, Selank prevents both the apathy of low dopamine and the restlessness of excess dopamine, contributing to a stable, focused emotional state.
Immune modulation: As a tuftsin analogue, Selank retains immunomodulatory properties – it can normalise the production of inflammatory cytokines that are often elevated during chronic stress and contribute to anxiety symptoms. This mind-body connection makes Selank uniquely effective for stress-related anxiety.
BDNF increase: Like Semax, Selank increases Brain-Derived Neurotrophic Factor, supporting neuroplasticity and cognitive function even while reducing anxiety.
Selank vs Traditional Anxiolytics
The comparison with benzodiazepines highlights Selank’s advantages: equivalent anxiety reduction without sedation, no tolerance development (the dose doesn’t need to increase over time), no physical dependency or withdrawal risk, no cognitive impairment (actually enhances cognition), and no interaction with alcohol. For individuals seeking anxiety relief who cannot afford the cognitive costs of traditional medications, Selank offers a compelling alternative.
Who Benefits from Selank?
Selank is ideal for individuals with generalised anxiety who want relief without sedation, professionals who need to remain sharp under high-stress conditions, those experiencing social anxiety who want confidence without impairment, people transitioning off benzodiazepines who need non-addictive support, and anyone with chronic stress-related inflammation affecting mood and well-being.
Clinical References
Selank, a Novel Anxiolytic Peptide, Modulates GABA-A Receptor Subunit Expression
Lan EL, Ugwu SO, Blanchard J, et al. Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide. J Pharm Sci. 1994;83(8):1081-1084. PubMed 7983590
Dorr RT, Lines R, Levine N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-1784. PubMed 8637402
Habbema L, Halk AB, Neumann M, et al. Risks of unregulated use of alpha-melanocyte-stimulating hormone analogues: a review. Int J Dermatol. 2017;56(10):975-980. PubMed 28266027
Gilhooley E, Daly S, McKenna D. Melanotan II user experience: a qualitative study of online discussion forums. Dermatology. 2021;237(6):995-999. PubMed 34464955
Bednarek MA, MacNeil T, Tang R, et al. Cyclic analogs of alpha-melanocyte-stimulating hormone (alphaMSH) with high agonist potency and selectivity at human melanocortin receptor 1b. Peptides. 2008;29(6):1010-1017. PubMed 18378043
Al-Obeidi F, Castrucci AM, Hadley ME, et al. Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics. J Med Chem. 1989;32(12):2555-2561. PubMed 2555512
Product specifications
Dosage
250mcg – 500mcg daily (loading), then as needed
Cycle
2–4 weeks loading, maintenance as needed
Form
10mg lyophilised powder
Purity
≥99%
Molecular formula
C₅₀H₆₉N₁₅O₉
Storage
2–8°C refrigerated
Dosing guide
Category-Specific Dosing Guides
Like many tanning & pigmentation peptides, MT-II is commonly used with a loading and maintenance approach. The loading phase is intended to build pigmentation, followed by less frequent dosing to maintain results.
1
Reconstitute
Add 2ml of BAC water to the 10mg vial, producing a concentration of 5mg/ml. At this concentration, each 5-unit mark on a U-100 insulin syringe delivers 250mcg.
One 10mg vial provides approximately 40 doses at 250mcg, which is typically sufficient for both the loading and maintenance phases.
2
Loading Phase (Weeks 1–4)
Early dosing typically falls within the 100-250mcg range. The dose is then increased to 250-500mcg daily. Subcutaneous injections are often taken in the evening. Brief UV exposure (10-15 minutes) every 2-3 days is commonly used alongside MT-II and helps activate melanocytes.
3
Maintenance
Once the target pigmentation level has been achieved, dosing will usually be lowered to 250-500 mcg once or twice a week, possibly even less than that.
It is common for users to maintain their pigmentation by taking doses every 1-2 weeks, along with some occasional UV exposure.
Managing Nausea
Nausea is regularly reported during the first few days when doses are high. Some of the approaches include taking a lower dose (100-250mcg) initially, injecting in the evening time, taking an antihistamine 30 minutes prior to the injection, and having a light meal about an hour before the procedure.
Many users report that nausea decreases during the first week as tolerance develops.
In the first human trial, 3 men got Melanotan II on alternate days. 2 of them had darker skin on the face, upper body and buttock a week after the last dose.
20 men with erectile dysfunction got Melanotan II or placebo in a crossover trial. Sexual desire went up after 68% of Melanotan II doses, against 19% on placebo. 17 of 20 men had an erection without sexual stimulation.
Scientists built a ring-shaped version of α-MSH, the structure now known as Melanotan II. On lizard skin it darkened pigment cells 90 times more strongly than natural α-MSH, and the effect lasted longer.
10 men with psychogenic erectile dysfunction got Melanotan II or placebo. 8 of 10 developed erections. Firm rigidity lasted 38.0 minutes on average, against 3.0 minutes on placebo.
Rats under chronic unpredictable stress got a low daily dose of Melanotan II. It reversed or eased their loss of interest in sugar water, a sign of low mood in rats. It also eased the drop in hippocampal BDNF.
Got a deep, golden tan in under two weeks with barely any sun time. Friends keep asking where I went on holiday. Great product.
2026-03-09
Works well for tanning. Had mild nausea on the first dose but it passed. Now on maintenance and the tan is holding great.
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How to use Melanotan II
Ready in 4 steps, BAC water included. A complete visual guide to preparing, reconstituting, injecting, and storing your peptides safely. Follow each step in order.
Preparation
1. Supplies laid outGather your supplies: peptide vial, bacteriostatic water, syringes, alcohol swabs, cotton ball, and bandage.2. Remove / flip capsRemove the plastic caps from both vials to expose the rubber stoppers.3. Swab the vial stopperWipe the top of each vial with an alcohol swab. Let air-dry.
4. Draw BAC waterDraw the required amount of bacteriostatic water into the syringe. Use our calculator if unsure.5. Inject water into vialInject the water slowly into the peptide vial, letting it run down the inside wall. Do not spray directly onto the powder.6. Swirl to dissolveGently swirl the vial until the powder dissolves. Do not shake.7. Check the solutionCheck the solution: no undissolved particles, no bubbles, clear liquid. If not, wait and swirl again.8. Draw your doseDraw your dose slowly from the reconstituted peptide vial.
9. Remove air bubblesHold the syringe needle-up, flick to move air bubbles to the top, and push the plunger until a small drop appears.10. Choose injection siteChoose your injection site: belly fat around the navel or outer thigh. Rotate sites between injections.11. Clean the siteClean the injection site with an alcohol swab.12. Pinch skinPinch a fold of skin at the injection site to lift the subcutaneous fatty tissue away from the muscle.13. Insert at 45°Insert the needle at a 45° angle into the subcutaneous fatty tissue, usually approximately half the needle length. Do not inject into muscle. Inject slowly.
14. Cotton-ball pressWithdraw the needle and press a cotton ball gently on the site for a few seconds.15. Apply bandageApply a small bandage.16. Sharps disposalDispose of the needle in a sharps container.17. StorageStore reconstituted peptides in the fridge (2-8 °C). Avoid freezing and direct sunlight. Use within 90 days.
Pre-filled for this product. Adjust values to match your protocol.
Increased pigmentation is usually seen within 5-7 days from the start of the loading phase. A visible tan often appears by week 2 and continues through weeks 34. Fair-skinned individuals (Fitzpatrick Types I-II) generally notice the strongest change. UV exposure of 10-15 minutes every 2-3 days is commonly used alongside Melanotan II.
Yes. Some UV exposure is usually recommended, as it helps activate melanocytes. For many users, 10-15 minutes every 2-3 days is enough.
Nausea is most commonly reported during the first 3-5 days. Starting with 100-250mcg, injecting in the evening, eating a light meal, and using an antihistamine before dosing are common approaches.
The duration varies between individuals. Some report that pigmentation fades gradually over 1-3 months after the final dose. Some people who buy Melanotan II online use maintenance dosing to help maintain pigmentation.
Yes. Existing moles and freckles can darken during use. Some users also report new freckles appearing. Individuals with a large number of moles may wish to have them monitored by a dermatologist.
Melanotan II1 free BAC water with every vial
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How to use Melanotan II
Our own 17-step illustrated guide, from mixing to storage.
