Sleep quality has genuinely improved. Falling asleep faster and waking up feeling rested. No grogginess like with melatonin.
Emma F. Verified Purchase
4.7 10 reviews

DSIP

The brain peptide studied for natural, deeper sleep.

  • Works with the body's own sleep cycle - not a sedative
  • Healthy volunteers slept 59% more within 130 minutes of a dose
  • Also studied for insomnia and stress hormones
99.735% purity PASS Janoshik Analytical, Prague - Batch P9X3W6
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£20,00
Bacteriostatic water 2ml vial FREE
1 free BAC water with every vial Worth £8 a bottle. Added automatically.
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How to use DSIP Our own 17-step illustrated guide, from mixing to storage.
Sleep quality has genuinely improved. Falling asleep faster and waking up feeling rested. No grogginess like with melatonin.
Emma F. Verified Purchase
Description

What Is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from the cerebral venous blood of rabbits during slow-wave sleep in 1977. This nine-amino acid peptide is found primarily in the brain, with the highest concentrations in the hypothalamus and limbic structures – the regions that govern sleep regulation, stress response, and hormonal balance.

Named for its ability to promote delta wave sleep (the deepest, most restorative stage of the sleep cycle), DSIP doesn’t act as a sedative. Instead, it modulates sleep architecture at the neurochemical level, increasing the proportion of time spent in deep sleep without altering total sleep duration. The result is sleep that is genuinely more restorative – you wake up feeling more recovered even if you sleep the same number of hours.

How DSIP Improves Sleep Quality

  • Delta wave enhancement: DSIP promotes the transition into and extends the duration of N3 (slow-wave/deep) sleep – the stage where growth hormone is released, tissues are repaired, memories are consolidated, and the immune system is restored.
  • Cortisol modulation: DSIP reduces elevated cortisol levels, particularly the nighttime cortisol spikes that disrupt sleep architecture and cause frequent awakenings. By normalising the cortisol rhythm, it helps restore the natural cortisol curve (low at night, rising in the morning).
  • LH and growth hormone support: DSIP has been shown to promote luteinising hormone (LH) release and support growth hormone secretion during sleep – both of which are critical for recovery, body composition, and hormonal health.
  • Stress and pain modulation: Beyond sleep, DSIP acts on endorphin systems and has demonstrated analgesic (pain-reducing) properties. Chronic pain sufferers often report improved sleep and reduced pain perception during DSIP use.
  • No sedation or dependency: Unlike benzodiazepines, Z-drugs, or even high-dose melatonin, DSIP does not cause sedation, morning grogginess, tolerance buildup, or withdrawal symptoms. It works by optimising your natural sleep mechanisms rather than overriding them.

Who Should Consider DSIP?

DSIP is ideal for individuals who sleep enough hours but wake up feeling unrested (poor sleep quality), those with stress-related sleep disruption and elevated nighttime cortisol, shift workers or travellers with disrupted circadian rhythms, chronic pain sufferers whose pain interferes with sleep, and athletes seeking to maximise recovery through enhanced deep sleep and growth hormone release.

Clinical References
Delta Sleep-Inducing Peptide (DSIP): A Still Unresolved Riddle
Kastin AJ, Bernstein HG, et al.

J Neurochem, 1999. PubMed →

Effect of Delta Sleep-Inducing Peptide on Sleep and Wakefulness
Graf MV, Kastin AJ

Pharmacol Biochem Behav, 1986. PubMed →

DSIP – A Tool for Studying the Sleep-Waking Cycle
Schoenenberger GA

Pharmacol Ther, 1984. PubMed →

Clinical References

  1. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. PubMed 16539679
  2. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. PubMed 265572
  3. Feldman SC, Kastin AJ. Localization of neurons containing immunoreactive delta sleep-inducing peptide in the rat brain: an immunocytochemical study. Neuroscience. 1984;11(2):303-317. PubMed 6371579
  4. Charnay Y, Leger L, Golaz J, et al. Immunohistochemical mapping of delta sleep-inducing peptide in the cat brain and hypophysis. Relationships with the LHRH system and corticotropes. J Chem Neuroanat. 1990;3(5):397-412. PubMed 2222894
  5. Graf MV, Kastin AJ. Delta sleep-inducing peptide (DSIP)-like material exists in peripheral organs of rats in large dissociable forms. Proc Soc Exp Biol Med. 1984;177(1):197-204. PubMed 6548030
  6. Schneider-Helmert D, Gnirss F, Monnier M, et al. Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. Int J Clin Pharmacol Ther Toxicol. 1981;19(8):341-345. PubMed 6895513
  7. Iyer KS, Marks GA, Kastin AJ, et al. Evidence for a role of delta sleep-inducing peptide in slow-wave sleep and sleep-related growth hormone release in the rat. Proc Natl Acad Sci U S A. 1988;85(10):3653-3656. PubMed 3368469
  8. Bjartell A, Ekman R, Bergquist S, et al. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. PubMed 2554357
  9. Schneider-Helmert D, Schoenenberger GA. Effects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep. Neuropsychobiology. 1983;9(4):197-206. PubMed 6689058
  10. Iyer KS, McCann SM. Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Res Bull. 1987;19(5):535-538. PubMed 3121137
  11. Nakamura A, Nakashima M, Sugao T, et al. Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP). Eur J Pharmacol. 1988;155(3):247-253. PubMed 2853064
  12. Nakamura A, Nakashima M, Sakai K, et al. Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro. Brain Res. 1989;481(1):165-168. PubMed 2706459
Product specifications
Dosage
100mcg – 300mcg before bedtime
Cycle
2–4 weeks
Form
5mg lyophilised powder
Purity
≥98%
Molecular formula
C₃₅H₄₈N₁₀O₁₅
Storage
2–8°C refrigerated
Certificate of Analysis
View COA
Dosing guide

Category-Specific Dosing Guides

DSIP is typically administered once daily before bedtime.

  1. 1

    Reconstitute

    Add 2ml of BAC water to the 5mg vial (2.5mg/ml = 2,500mcg/ml). Each 4 units on a U-100 syringe equals 100mcg. One vial provides approximately 16-50 doses, depending on the amount administered.

  2. 2

    Timing & Dosage

    Injection of 100-300mcg subcutaneously should be done 30-60 minutes before the intended bedtime. The first dose should begin at 100mcg but may be increased to 200-300mcg if appropriate. Anyone looking to buy DSIP online will likely come across dosing ranges between 100mcg and 300mcg.

  3. 3

    Cycle

    Run for 2-4 weeks, then take 2 weeks off. Cycles are commonly repeated following the 2-week break period. DSIP is commonly discussed in relation to sleep architecture and circadian physiology during these protocols.

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Sleep rose 59% in the 130 minutes after a DSIP dose

In the first human study, healthy volunteers slept 59% more after a DSIP infusion than after placebo. Tests showed no sedation in the classic drug sense.

Lifespan - mice

24% longer maximum lifespan in mice

SalineBaseline
DSIP+24.1%

Mice got a DSIP preparation 5 days a month from 3 months of age until death. Maximum lifespan was 24.1% longer than with saline, and chromosome damage in bone marrow cells fell 22.6%. Average lifespan did not change.

Popovich et al., Mechanisms of Ageing and Development, 2003
Insomnia
14 adults with chronic insomnia - human trial

Sleep efficiency reached normal levels

Middle-aged adults with chronic insomnia got DSIP for 7 nights in a double-blind, placebo-controlled trial. Night sleep improved from the first dose. Sleep efficiency reached the level of normal sleepers and daytime alertness rose.

Schneider-Helmert, European Neurology, 1987
Follow-up
7 patients with severe insomnia - open study

6 of 7 still sleeping normally months later

Patients got a series of 10 DSIP injections. In all but one, sleep stayed normal for 3 to 7 months of follow-up. Mood and daytime performance also improved.

Kaeser, European Neurology, 1984
Stress hormones
11 healthy men - human trial

Lower ACTH for at least 3 hours

One DSIP dose lowered ACTH, the hormone that triggers the stress response, for at least 3 hours compared with saline. Cortisol kept its normal daily pattern.

Bjartell et al., Psychoneuroendocrinology, 1989

Sources: Schneider-Helmert D, Gnirss F, Monnier M, Schenker J, Schoenenberger GA, International Journal of Clinical Pharmacology, Therapy, and Toxicology 1981;19(8):341-5; Popovich IG et al., Mechanisms of Ageing and Development 2003;124(6):721-31; Schneider-Helmert D, European Neurology 1987;27(2):120-9; Kaeser HE, European Neurology 1984;23(5):386-8; Bjartell A, Ekman R, Bergquist S, Widerlöv E, Psychoneuroendocrinology 1989;14(5):347-55

Rated 4.7 by verified buyers

Customer rating 4.7 Based on 10 reviews Write a review
2026-03-18

Sleep quality has genuinely improved. Falling asleep faster and waking up feeling rested. No grogginess like with melatonin.

Emma F. Verified Purchase
2026-03-02

Game changer for my sleep. I work shifts and DSIP has helped me reset my circadian rhythm when rotating schedules.

Rasmus T. Verified Purchase

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    How to use DSIP

    Ready in 4 steps, BAC water included. A complete visual guide to preparing, reconstituting, injecting, and storing your peptides safely. Follow each step in order.

    Step 1: Supplies laid out
    1. Supplies laid out Gather your supplies: peptide vial, bacteriostatic water, syringes, alcohol swabs, cotton ball, and bandage.
    Step 2: Remove / flip caps
    2. Remove / flip caps Remove the plastic caps from both vials to expose the rubber stoppers.
    Step 3: Swab the vial stopper
    3. Swab the vial stopper Wipe the top of each vial with an alcohol swab. Let air-dry.
    Step 4: Draw BAC water
    4. Draw BAC water Draw the required amount of bacteriostatic water into the syringe. Use our calculator if unsure.
    Step 5: Inject water into vial
    5. Inject water into vial Inject the water slowly into the peptide vial, letting it run down the inside wall. Do not spray directly onto the powder.
    Step 6: Swirl to dissolve
    6. Swirl to dissolve Gently swirl the vial until the powder dissolves. Do not shake.
    Step 7: Check the solution
    7. Check the solution Check the solution: no undissolved particles, no bubbles, clear liquid. If not, wait and swirl again.
    Step 8: Draw your dose
    8. Draw your dose Draw your dose slowly from the reconstituted peptide vial.
    Step 9: Remove air bubbles
    9. Remove air bubbles Hold the syringe needle-up, flick to move air bubbles to the top, and push the plunger until a small drop appears.
    Step 10: Choose injection site
    10. Choose injection site Choose your injection site: belly fat around the navel or outer thigh. Rotate sites between injections.
    Step 11: Clean the site
    11. Clean the site Clean the injection site with an alcohol swab.
    Step 12: Pinch skin
    12. Pinch skin Pinch a fold of skin at the injection site to lift the subcutaneous fatty tissue away from the muscle.
    Step 13: Insert at 45°
    13. Insert at 45° Insert the needle at a 45° angle into the subcutaneous fatty tissue, usually approximately half the needle length. Do not inject into muscle. Inject slowly.
    Step 14: Cotton-ball press
    14. Cotton-ball press Withdraw the needle and press a cotton ball gently on the site for a few seconds.
    Step 15: Apply bandage
    15. Apply bandage Apply a small bandage.
    Step 16: Sharps disposal
    16. Sharps disposal Dispose of the needle in a sharps container.
    Step 17: Storage
    17. Storage Store reconstituted peptides in the fridge (2-8 °C). Avoid freezing and direct sunlight. Use within 90 days.

    Pre-filled for this product. Adjust values to match your protocol.

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    Frequently Asked Questions